Journal
CLINICAL NEUROPSYCHOLOGIST
Volume 21, Issue 1, Pages 58-72Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/13854040601064542
Keywords
blood flow; CBF; fMRI; functional imaging; lesions; TBI
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Funding
- NICHD NIH HHS [HD07522] Funding Source: Medline
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There is a rapid v growing literature using fMRI technology to investigate the various forms of behavioral impairment associated with brain injury and disease. Given this, surprisingly little work has been conducted to examine the influence of neuropathophysiological processes on the fMRI signal. This paper reviews the literature examining baseline alteration in cerebrovascular parameters associated with normal aging, brain injury, and brain disease. In addition, findings from three cases of individuals with severe brain trauma will be presented to show the influence of brain trauma on baseline cerebro vascular parameters measured by fMRI. The methods used here can be implemented by other investigators to accurately isolate specific hemodynamic changes that can influence the BOLD fMRI signal.
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