Journal
CLINICAL MICROBIOLOGY AND INFECTION
Volume 13, Issue 1, Pages 19-24Publisher
ELSEVIER SCI LTD
DOI: 10.1111/j.1469-0691.2006.01557.x
Keywords
CD4(+)/CD8(+) T-cells; cytomegalovirus; highly active anti-retroviral therapy (HAART); human immunodeficiency virus; immune function; protective immunity
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A new technique was used to simultaneously determine human cytomegalovirus (HCMV)-specific CD4(+) and CD8(+) T-cells in highly active anti-retroviral therapy (HAART)-naive and HAART-treated patients infected with human immunodeficiency virus (HIV). HIV-infected patients with HCMV infection, but without HCMV disease, showed low numbers of HCMV-specific CD4(+) cells and high numbers of CD8(+) T-cells, both before and during HAART. HIV-infected patients with HCMV disease had no HCMV-specific CD4(+) T-cells and extremely low levels of CD8(+) T-cells. Resolution of disease during HAART was associated with rescue of specific CD4(+) T-cells and a large increase in the specific CD8(+) T-cell count. Thus, HAART does not completely restore the normal immune function. In HIV-infected patients, sustained control of HCMV infection requires high frequencies of specific CD8(+) T-cells.
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