Journal
HELVETICA CHIMICA ACTA
Volume 90, Issue 12, Pages 2401-2413Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200790247
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A new synthetic route for biologically interesting benzochromenes was developed starting from naphthalenols and alpha,beta-unsaturated aldehydes in the presence of ethylenediamine diacetate. This methodology was applied for the total synthesis of the biologically important natural products lapachenole, dihydrolapachenole, and mollugin with a benzochromene moiety.
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