Journal
CANCER RESEARCH
Volume 68, Issue 8, Pages 2557-2560Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-07-5989
Keywords
-
Categories
Funding
- NCI NIH HHS [T32CA9056] Funding Source: Medline
- NHLBI NIH HHS [HL75826, T32HL086345, HL83077] Funding Source: Medline
Ask authors/readers for more resources
Misfolded or aggregated proteins have two fates: they are either refolded with the help of chaperones or degraded by the proteasome. Cells also have an alternative pathway that involves intracellular storage bins for misfolded intracellular proteins known as aggresomes. Aggresomes recruit motor proteins that transport misfolded or aggregated proteins to chaperones and proteasomes for subsequent destruction. There is emerging evidence that inhibiting the aggresome pathway leads to accumulation of misfolded proteins and apoptosis in tumor cells through autophagy. We discuss the role of aggresomes in cancer and the potential to target this pathway for therapy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available