Journal
CANCER RESEARCH
Volume 68, Issue 17, Pages 6873-6876Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-08-0547
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Studies in model organisms or cultured human cells suggest. potential implications in carcinogenesis for the AAA+ ATPases Pontin and Reptin. Both proteins are associated with several chromatin-remodeling complexes and have many functions including transcriptional regulation, DNA damage repair, and telomerase activity. They also interact with major oncogenic actors such as beta-catenin and c-myc and regulate their oncogenic function. We only now begin to get. insight into the role of Pontin and Reptin in human cancers.
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