Solvent-free one-pot four-component synthesis of 2-aminomorpholines. Access to related diaminoalcohols

Under microwave irradiation, a series of 2-aminomorpholines were readily produced in a straightforward four-component process from commercially available 1,2-aminoalcohols, glyoxal, boronic acids and aliphatic or aromatic amines. Further reduction furnished the corresponding diaminoalcohols.