Journal
CANCER RESEARCH
Volume 68, Issue 6, Pages 1614-1617Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/0008-5472.CAN-07-6012
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Funding
- NCI NIH HHS [R01 CA120777-01, CA103642, R01 CA103642, R01 CA120777, R01 CA120777-03, P30 CA023108, R01 CA120777-02] Funding Source: Medline
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Antitumor immune responses can be stimulated by interfering with regulatory T-cell (T-reg) function. However, this effect is short lived unless T-cell memory to tumor antigens can be generated. Our recent studies show that T-reg cells not only limit primary responses to tumor/self-antigens in tumor-bearing hosts but also prevent the natural generation of T-cell memory to such antigens. Here, we discuss the role of T-reg cells in suppressing T-cell memory after surgical excision of tumors and the potential clinical benefits of overcoming this suppression.
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