Journal
HELVETICA CHIMICA ACTA
Volume 90, Issue 7, Pages 1391-1398Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/hlca.200790141
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Chemical investigation of the gorgonian coral Junceella fragilis, collected by scuba diving in Taiwan, resulted in the isolation of four new briarane-type diterpenoids, frajunolides A-D (1-4), along with three known briaranes. Their structures were elucidated on the basis of spectroscopic studies, especially 1- and 2D-NMR as well as HR-MS experiments. The inhibitory effect of all isolated metabolites towards superoxide-anion generation and elastase release by human neutrophils in response to formylmethionyl-leucyl-phenylalanine/dihydrocytochalasin B (FMLP/CB) was evaluated.
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