Chemical constituents of the endophytic fungal strain Phomopsis sp NXZ-05 of Camptotheca acuminata

From the endophytic fungal strain Phomopsis sp. NXZ-05 of Camptotheca acuminata DECNE. (Nyssaceae), six new compounds were isolated, including the ten-membered macrolides 1-4 and their (known) parent compound multiplolide A (7), as well as a new unsaturated fatty acid, (4E)-6,7,9-trihydroxydec-4-enoic acid (5) and its methyl ester 6. Their structures were elucidated by spectroscopic and mass-spectrometric analyses, including 1D- and 2D-NMR experiments and HR-ESI-MS, and their biological activities were elucidated.