Journal
NATURE CELL BIOLOGY
Volume 9, Issue 1, Pages 2-6Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncb0107-2
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Funding
- Biotechnology and Biological Sciences Research Council [G18987] Funding Source: Medline
- Medical Research Council [G0300332] Funding Source: Medline
- MRC [G0300332] Funding Source: UKRI
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The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.
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