Journal
CHEMISTRY & BIODIVERSITY
Volume 4, Issue 5, Pages 998-1002Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.200790091
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A new cardenolide, 3-O-(beta-glucopyranosyl)acoveiiosigenin A (1), was isolated from the roots of Strcptocaulon griffithii, together with eight known cardenolides, compounds 2-9. All compounds showed significant in vitro inhibition of the proliferation of the human gastrointestinal cancer cell line HGC-27, with IC50 values in the range of ca. 20-564 nM, taxol being used as positive control. Compound 1 was also found to be strongly cytotoxic against other human tumor cell lines, including A549, MCF-7, and Hela cells.
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