Journal
NATURE REVIEWS GENETICS
Volume 8, Issue 9, Pages 699-710Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2144
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Funding
- NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES [R01ES014811] Funding Source: NIH RePORTER
- NIEHS NIH HHS [R01 ES014811-01A1, R01 ES014811-04, R01 ES014811-03, ES014811, R01 ES014811-02, R01 ES014811-02S1, R01 ES014811] Funding Source: Medline
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Physical and genetic mapping data have become as important to network biology as they once were to the Human Genome Project. Integrating physical and genetic networks currently faces several challenges: increasing the coverage of each type of network; establishing methods to assemble individual interaction measurements into contiguous pathway models; and annotating these pathways with detailed functional information. A particular challenge involves reconciling the wide variety of interaction types that are currently available. For this purpose, recent studies have sought to classify genetic and physical interactions along several complementary dimensions, such as ordered versus unordered, alleviating versus aggravating, and first versus second degree.
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