Journal
NATURE REVIEWS CANCER
Volume 7, Issue 9, Pages 684-700Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc2196
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Epidemiological studies indicate that vitamin D insufficiency could have an aetiological role in various human cancers. Preclinical research indicates that the active metabolite of vitamin D, 1 alpha, 25( OH)(2) D-3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. In addition, 1 alpha, 25( OH)(2) D-3 potentiates the anticancer effects of many cytotoxic and antiproliferative anticancer agents. Here, we outline the epidemiological, preclinical and clinical studies that support the development of 1 alpha, 25(OH)(2) D-3 and vitamin D analogues as preventative and therapeutic anticancer agents.
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