Journal
MICROBES AND INFECTION
Volume 9, Issue 11, Pages 1333-1340Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.micinf.2007.06.007
Keywords
influenza virus; H5N1 subtype; ampligen; adjuvant; immunoglobulin A
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The avian H5N1 influenza virus has the potential to cause a new pandemic. Since it is difficult to predict which strain of influenza will cause a pandemic, it is advantageous to produce vaccines that confer cross-protective immunity. Mucosal vaccine administration was reported to induce cross-protective immunity by inducing secretion of IgA at the mucosal surface. Adjuvants can also enhance the development of fully protective mucosal immunity. Here we show that a new mucosal adjuvant, polyI:polyC(12)U (Ampligen (R)), a Toll-like receptor 3 agonist proven to be safe in a Phase III human trial, is an effective adjuvant for H5N1 influenza vaccination. Intranasal administration of a candidate influenza vaccine with Ampligen resulted in secretion of IgA, and protected mice that were subsequently challenged with homologous A/Vietnam/1194/2004 and heterologous A/HK/483/97 and A/Indonesia/6/2005 virus. (C) 2007 Elsevier Masson SAS. All rights reserved.
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