Journal
DEVELOPMENTAL CELL
Volume 12, Issue 4, Pages 487-502Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2007.03.020
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Funding
- NATIONAL CANCER INSTITUTE [R01CA090764] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG016927] Funding Source: NIH RePORTER
- NCI NIH HHS [CA090764] Funding Source: Medline
- NIA NIH HHS [AG016927] Funding Source: Medline
- PHS HHS [AB025953] Funding Source: Medline
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The regulatory circuits that control the activities of the two distinct target of rapamycin (TOR) complexes, TORC1 and TORC2, and of Akt have been a focus of intense research in recent years. It has become increasingly evident that these regulatory circuits control some of the most fundamental aspects of metabolism, cell growth, proliferation, survival, and differentiation at both the cellular and organismal levels. As such, they also play a pivotal role in the genesis of diseases including cancer, diabetes, aging, and degenerative diseases. This review highlights recent developments aimed at deciphering the interplay between Akt and mTORCs as well as their role in embryonic development and in cancer.
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