Journal
NATURE REVIEWS GENETICS
Volume 8, Issue 4, Pages 253-262Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrg2045
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- NIEHS NIH HHS [R01 ES012974] Funding Source: Medline
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Epidemiological evidence increasingly suggests that environmental exposures early in development have a role in susceptibility to disease in later life. In addition, some of these environmental effects seem to be passed on through subsequent generations. Epigenetic modifications provide a plausible link between the environment and alterations in gene expression that might lead to disease phenotypes. An increasing body of evidence from animal studies supports the role of environmental epigenetics in disease susceptibility. Furthermore, recent studies have demonstrated for the first time that heritable environmentally induced epigenetic modifications underlie reversible transgenerational alterations in phenotype. Methods are now becoming available to investigate the relevance of these phenomena to human disease.
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