The neuronal background K-2P channels: focus on TREK1

Two-pore-domain K+ (K-2P) channel subunits are made up of four transmembrane segments and two pore-forming domains that are arranged in tandem and function as either homo- or heterodimeric channels. This structural motif is associated with unusual gating properties, including background channel activity and sensitivity to membrane stretch. Moreover, K-2P channels are modulated by a variety of cellular lipids and pharmacological agents, including polyunsaturated fatty acids and volatile general anaesthetics. Recent in vivo studies have demonstrated that TREK1, the most thoroughly studied K-2P channel, has a key role in the cellular mechanisms of neuroprotection, anaesthesia, pain and depression.