Journal
BIOCHIMIE
Volume 89, Issue 4, Pages 490-499Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2007.02.012
Keywords
topoisomerase II; DNA supercoiling; DNA wrapping; DNA topology; gyrase
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Funding
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM031655] Funding Source: NIH RePORTER
- NIGMS NIH HHS [GM31655] Funding Source: Medline
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The level of negative DNA supercoiling of the Escherichia coli chromosome is tightly regulated in the cell and influences many DNA metabolic processes including DNA replication, transcription, repair and recombination. Gyrase is the only type 11 topoisomerase able to introduce negative supercoils into DNA, a unique ability that arises from the specialized C-terminal DNA wrapping domain of the GyrA subunit. Here, we review the biological roles of gyrase in vivo and its mechanism in vitro. (C) 2007 Elsevier Masson SAS. All rights reserved.
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