Journal
NATURE REVIEWS MICROBIOLOGY
Volume 5, Issue 3, Pages 197-208Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1615
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Funding
- NIGMS NIH HHS [R01 GM068518, R01 GM068518-05] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM068518] Funding Source: NIH RePORTER
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What could be a better way to study virus trafficking than 'miniaturizing oneself' and 'taking a ride with the virus particle' on its journey into the cell? Single-virus tracking in living cells potentially provides us with the means to visualize the virus journey. This approach allows us to follow the fate of individual virus particles and monitor dynamic interactions between viruses and cellular structures, revealing previously unobservable infection steps. The entry, trafficking and egress mechanisms of various animal viruses have been elucidated using this method. The combination of single-virus trafficking with systems approaches and state-of-the-art imaging technologies should prove exciting in the future.
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