Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 8, Issue 3, Pages 209-220Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm2124
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Funding
- NIGMS NIH HHS [R01 GM053034, R01 GM053034-11, R01 GM053034-12, R01 GM054682, R01 GM066958] Funding Source: Medline
- NINDS NIH HHS [R01 NS041617-08, R01 NS041617] Funding Source: Medline
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM054682, R01GM053034, R01GM066958] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS041617] Funding Source: NIH RePORTER
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Recent advances have fuelled rapid growth in our appreciation of the tremendous number, diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically function as ribonucleoprotein (RNP) complexes and not as naked RNAs, understanding their biogenesis is crucial to comprehending their regulation and function. The small nuclear and small nucleolar RNPs are two well studied classes of ncRNPs with elaborate assembly and trafficking pathways that provide paradigms for understanding the biogenesis of other ncRNPs.
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