Journal
NATURE REVIEWS NEUROSCIENCE
Volume 8, Issue 3, Pages 171-181Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn2092
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Sleep and wakefulness are regulated to occur at appropriate times that are in accordance with our internal and external environments. Avoiding danger and finding food, which are life-essential activities that are regulated by emotion, reward and energy balance, require vigilance and therefore, by definition, wakefulness. The orexin (hypocretin) system regulates sleep and wakefulness through interactions with systems that regulate emotion, reward and energy homeostasis.
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