Journal
POSTGRADUATE MEDICAL JOURNAL
Volume 83, Issue 977, Pages 148-151Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/pgmj.2006.049734
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In order to compensate for the low partial pressure of oxygen at altitude, the human body undergoes a number of physiological changes. A vital component in this process is the increase in the concentration of circulating haemoglobin. The role of HIF-1 alpha, erythropoietin and red blood cells in this acclimatisation process is described, together with the fall in plasma volume that increases the concentration of haemoglobin in the early stages of hypoxic exposure.
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