Journal
NATURE REVIEWS MICROBIOLOGY
Volume 5, Issue 3, Pages 187-196Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrmicro1579
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Funding
- Intramural NIH HHS Funding Source: Medline
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [ZIADK036171, Z01DK036171] Funding Source: NIH RePORTER
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Human immunodeficiency virus 1 (HIV-1) and other retroviruses synthesize a DNA copy of their genome after entry into the host cell. Integration of this DNA into the host cell's genome is an essential step in the viral replication cycle. The viral DNA is synthesized in the cytoplasm and is associated with viral and cellular proteins in a large nucleoprotein complex. Before integration into the host genome can occur, this complex must be transported to the nucleus and must cross the nuclear envelope. This Review summarizes our current knowledge of how this journey is accomplished.
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