Journal
AVIAN DISEASES
Volume 51, Issue 1, Pages 393-395Publisher
AMER ASSOC AVIAN PATHOLOGISTS
DOI: 10.1637/7645-050906R1.1
Keywords
influenza; reverse genetics
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/C516495/2] Funding Source: Medline
- Medical Research Council [MC_U117585868] Funding Source: Medline
- MRC [MC_U117585868] Funding Source: UKRI
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We previously described the use of an established reverse genetics system for the generation of recombinant human influenza A viruses from cloned cDNAs. Here, we have assembled a set of plasmids to allow recovery of the avian H5N1 influenza virus A/Turkey/England/50-92/91 entirely from cDNA. This system enables us to introduce mutations or truncations into the cDNAs to create mutant viruses altered specifically in a chosen gene. These mutant viruses can then be used in future pathogenesis studies in chickens and in studies to understand the host range restrictions of avian influenza viruses in humans.
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