Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 50, Issue 2, Pages 308-313Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2006.08.012
Keywords
Alzheimer's dementia; kynurenine pathway; kynurenic acid; kynurenine aminotransferase; apolipoprotein E
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Kynurenine aminotransferases (KAT I and KAT 11) are responsible for the transamination of kynurenine (KYN) to form kynurenic acid (KYNA), an excitatory amino acid receptor antagonist. Since these members of the kynurenine pathway (KP) are proposed to be involved in the pathogenesis of Alzheimer's dementia (AD), the activities of these enzymes and the levels of these metabolites were measured in the plasma and red blood cells (RBCs) of AD and control subjects together with the inheritance of the apolipoprotein (APOE) epsilon 4 allele. KYNA levels were significantly decreased both in the plasma and in the RBCs in AD, but the levels of KYN and the activities of KAT I and KAT 11 remained unchanged. No association has been found with the possession of the F,4 allele. These findings indicate an altered peripheral KP in AD regardless of the APOE status of the probands. (c) 2006 Published by Elsevier Ltd.
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