Journal
NATURAL PRODUCT RESEARCH
Volume 21, Issue 5, Pages 436-443Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410600943288
Keywords
Jussiaea repens; Onagraceae; aerial parts; quercetin and kaempferol 3-O-glycosides; hepatoprotective activity; anti-inflammatory activity; antidiabetic activity
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A new acylated avicularin, namely avicularin 200-(4000-O-n- pentanoyl)- gallate ( 1) along with 12 metabolites have been isolated from the ethyl acetate extract of the aerial parts of Jussiaea repens L. ( Onagraceae). Their structures were established as trifolin 2-O-gallate ( 2), quercetrin ( 3), guaijaverin ( 4), reynoutrin ( 5), juglanin ( 6), avicularin ( 7), hyperin ( 8), trifolin ( 9), hyperin 2-O-gallate ( 10), rutin ( 11), kaempferol ( 12) and quercetin ( 13) on the basis of their chromatographic properties, chemical and spectroscopic evidences. The investigated ethyl acetate extract was found to be non-toxic (LD50 up to the maximum soluble dose 4 g kg(-1) body wt.) and had significant antioxidant, hepatoprotective, anti-inflammatory and antidiabetic activities. Also some of the isolated flavonoids showed cytotoxic activity against Ehrlich ascitis carcinoma cells.
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