Journal
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
Volume 28, Issue 8, Pages 1254-1261Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/01932690701528241
Keywords
bioavailability; nanoemulsions; flutamide; 1-O-alkylglycerols
Categories
Ask authors/readers for more resources
Size of oil globule and emulsifier film covering it are the key factors modifying oral absorption of drugs dissolved/dispersed in oil globules of o/w emulsions. Since oral bioavailability of flutamide (FTM) is poor, nanoemulsions incorporating FTM in oil phase and globules stabilized by a novel lipophilic emulsifier, 1-O-alkylglycerol were developed and characterized. All nanoemulsions had a size around 200 nm. They exhibited considerable release retardation in vitro. Flutamide nanoemulsions were evaluated for oral bioavailability in rabbits and in situ intestinal absorption in rats. Serum level data of flutamide obtained in the in situ experiments indicate higher FTM absorption from nanoemulsions than the aqueous FTM suspension. Among the nanoemulsions, 1-O-alkylglycerol stabilized systems showed higher absorption. The results of bioavailability studies in rabbits indicate increased absorption and decreased elimination of FTM from nanoemulsions, thus improving the bioavailability. Increased rate of absorption of flutamide in the in situ experiments can be attributed to the permeation enhancement effect of 1-O-alkylglycerols. However, size of the oil droplet seems to be the major factor in improving oral bioavailability in rabbits.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available