Journal
ORGANIC PROCESS RESEARCH & DEVELOPMENT
Volume 11, Issue 1, Pages 81-85Publisher
AMER CHEMICAL SOC
DOI: 10.1021/op060200g
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Telmisartan (1), a substituted dibenzimidazole derivative, is an antihypertensive drug, essentially used to control blood pressure. An improved, cost-effective, and impurity-free process for telmisartan (1) suitable for large-scale production is described here by addressing various process development issues. The overall yield obtained from this newly developed process is around 50% (over five steps) compared to the literature reported process (21%, over eight steps).
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