Journal
NATURAL PRODUCT RESEARCH
Volume 21, Issue 6, Pages 555-563Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14786410601133517
Keywords
meridianins; marine natural products; indole alkaloids; tandem mass spectrometry; constant neutral loss
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As part of the development of an analytical technique for the detection of meridianins and related compounds in biological fluids, a crude extract of the tunicate Aplidium meridianum was analysed using neutral loss tandem mass spectrometry. The 41 u neutral loss- EI(+) mass spectrum showed molecular ions corresponding to two previously undetected alkaloids. We report herein the isolation and structure elucidation of these alkaloids, meridianins F and G.
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