Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1773, Issue 1, Pages 78-88Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2006.08.033
Keywords
cancer progression; EMT; cell-cell adhesion; Armadillo; catenin; cadherin; Rho GTPase
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p120ctn is a member of the Armadillo protein family. It stabilizes the cadherin-catenin adhesion complex at the plasma membrane, but also has additional roles in the cytoplasm and nucleus. Extensive alternative mRNA splicing and multiple phosphorylation sites generate additional complexity. Evidence is emerging that complete loss, downregulation or mislocalization of p120ctn correlates with progression of different types of human tumors. It remains to be determined whether a causal relationship exists between specific isoform expression, subcellular localization or selective phosphorylation of p120ctn on the one hand and tumor prognosis on the other. (c) 2006 Elsevier B.V. All rights reserved.
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