Journal
PHYTOMEDICINE
Volume 14, Issue 2-3, Pages 222-226Publisher
ELSEVIER GMBH
DOI: 10.1016/j.phymed.2006.01.012
Keywords
Erythrina lysistemon; ethyl-acetate extract; uterotrophy; estrogenicity
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The stem bark of Erythrina lysistemon, one of the traditionally used women remedies, has been assessed for its estrogenic activity. The ethyl-acetate extract of the stem bark of E lysistemon showed estrogenic activities in vitro either in a yeast-based estrogen receptor assay or on the estrogen-dependent stimulation of alkaline phosphatase activity in the human endometrial carcinoma cell line Ishikawa. The estrogenic activity was investigated in vivo in young ovariectornized Wistar female rats after a 7-day treatment. The estrogenicity was evaluated through the proliferative status of target sex organs such as uterus and vagina. The results obtained showed that oral administration of 200 mg/kg BW/d of E lysistemon extract in comparison to untreated ovariectomized rats significantly increased the vaginal epithelial height by 47.23% (from 8.71 +/- 0.47 to 12.34 +/- 1.31 mu m); and induced a weak increase of uterine epithelial height by 6.76% (from 5.42 +/- 0.52 to 5.84 +/- 0.91 mu m). Both were not as pronounced as those elicited in the positive control of 100 mu g/kg BW/d of ethinylestradiol given orally. Overall our results suggest that the extract of E lysistemon contains secondary metabolites endowed with estrogenic activity. (c) 2006 Elsevier GmbH. All rights reserved.
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