Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 50, Issue 2, Pages 371-378Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2006.09.011
Keywords
GABA neurotransmission; acetate metabolism; in vivo magnetic resonance spectroscopy
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Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [ZICMH002894, Z01MH002894] Funding Source: NIH RePORTER
- Intramural NIH HHS Funding Source: Medline
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Brain [2-C-13] gamma-aminobutyric acid (GABA) signal derived from the glia-specific substrate [2-C-13]acetate reflects the extent of the GABA-glutamine neurotransmitter cycling between GABAergic neurons and glial cells. We report, for the first time, in vivo quantification of the GABA-glutamine cycling flux. The GABA-glutamine cycling flux rate was determined to be 1.8 +/- 0.4 mu mol/(g h) (mean +/- S.D., n = 6, similar to 6% of total tricarboxylic acid cycle rate) in the neocortex of vigabatrin-treated rats. The relatively small magnitude of glial contribution to the clearance of extracellular GABA measured in this study provided in vivo evidence to support the concept of a significant neuronal reuptake of GABA, which short-circuits the GABA-glutamine cycling pathway for repletion of released neurotransmitter GABA. (c) 2006 Elsevier Ltd. All rights reserved.
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