Journal
NATURE CLINICAL PRACTICE ONCOLOGY
Volume 4, Issue 9, Pages 516-525Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/ncponc0908
Keywords
breast cancer; self-renewal; stem cell; subtypes; therapy
Categories
Funding
- Breast Cancer Now [2006MAYSF01] Funding Source: Medline
Ask authors/readers for more resources
This Review summarizes and evaluates the current evidence for the cellular origins of breast cancer subtypes identified by different approaches such as histology, molecular pathology, genetic and gene-expression analysis. Emerging knowledge of the normal breast cell types has led to the hypothesis that the subtypes of breast cancer might arise from mutations or genetic rearrangements occurring in different populations of stem cells and progenitor cells. We describe the common distinguishing features of these breast cancer subtypes and explain how these features relate both to prognosis and to selection of the most appropriate therapy. Recent data indicate that breast tumors may originate from cancer stem cells. Consequently, inhibition of stem-cell self-renewal pathways should be explored because of the likelihood that residual stem cells might be resistant to current therapies.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available