Cytotoxic triterpene glycosides from the sea cucumber Pseudocolochirus violaceus

A new triterpene glycoside (1) along with the known intercedenside B (2) was isolated from the sea cucumber Pseudocolochirus violaceus. Glycoside 1 was elucidated as 3-O-{6-O-sodiumsulfate-3-O-methyl-beta -D-glucopyranosyl-(1 -> 3)-beta-D-xylopyranosyl(1 -> 4)-[beta-D-xylopyranosyl(1 -> 2)]-beta-D-quinovopyranosyl-(1 -> 2)4-O-sodiumsulfate-beta-D-xylopyranosy}- 16 beta-acetoxy-holosta-7, 24-diene-3 beta-ol on the basis of extensive spectral studies and chemical evidence. Both the glycosides exhibited significant cytotoxicity against cancer cell lines MKN-45 and HCT-116. (c) 2007 Elsevier B.V. All rights reserved.