Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 37, Issue 5, Pages 465-473Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2006.12.012
Keywords
gene manipulation; schistosome; RNA interference; transgenesis; transfection; transformation; transduction; particle bombardment; biolistics; electroporation; reporter; promoter; parasitic helminth; functional genomics
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In contrast to the situations with model organisms and parasitic protozoa, progress with gene manipulation with schistosomes has been delayed by impediments that include our inability to maintain the life cycle in vitro, absence of immortalized cell lines, large genome sizes, unavailability of drug resistance markers and other difficulties. However, in the past few years, tangible progress has been reported towards development of tools for gene manipulation and transgenesis of schistosomes, and there is reason to believe that the field is on the verge of transformation into an era where genetic manipulation is routine. Recent reports dealing with approaches and tools to manipulate the genome and gene expression in schistosomes are reviewed here. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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