Journal
MOLECULAR AND CELLULAR NEUROSCIENCE
Volume 34, Issue 4, Pages 493-502Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.mcn.2007.01.001
Keywords
glutamate; LTP; LTD; AMPA receptor; NMDA receptor; kainate receptor; critical period
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [Z01NS003011] Funding Source: NIH RePORTER
- Intramural NIH HHS [001-1789-088, Z99 NS999999] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
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The thalamocortical (TC) input to layer IV provides the major pathway for ascending sensory information to the mammalian sensory cortex. During development there is a dramatic refinement of this input that underlies the maturation of the topographical map in layer IV. Over the last 10 years our understanding of the mechanisms of the developmental and experience-driven changes in synaptic function at TC synapses has been greatly advanced. Here we describe these studies that point to a key role for NMDA receptor-dependent synaptic plasticity, a role for kainate receptors and for a rapid maturation in GABAergic inhibition. The expression mechanisms of some of the forms of neonatal synaptic plasticity are novel and, in combination with other mechanisms, produce a layer IV circuit that exhibits functional properties necessary for mature sensory processing. (c) 2007 Elsevier Inc. All rights reserved.
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