Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volume 1771, Issue 3, Pages 299-309Publisher
ELSEVIER
DOI: 10.1016/j.bbalip.2006.07.001
Keywords
triacylglycerol; steryl ester; lipid particle; acyltransferase; lipase; yeast
Funding
- Austrian Science Fund (FWF) [W 901] Funding Source: researchfish
- Austrian Science Fund FWF [W 901] Funding Source: Medline
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The single cell eukaryote Saccharomyces cerevisiae is an attractive model to study the complex process of neutral lipid (triacylglycerol and steryl ester) synthesis, storage and turnover. In mammals, defects in the metabolism of these lipids are associated with a number of severe diseases such as atherosclerosis, obesity and type II diabetes. Since the yeast harbors many counterparts of mammalian enzymes involved in these pathways, conclusions drawn from research with the microorganism can be readily applied to the higher eukaryotic system. Here, we summarize our current knowledge of yeast neutral lipid metabolism, report about pathways and enzymes contributing to formation and degradation of triacylglycerols and steryl esters, and describe storage of these components in lipid particles. The interplay of different subcellular compartments in neutral lipid metabolism, regulatory aspects of this process and cell biological consequences of dysfunctions will be discussed. (c) 2006 Elsevier B.V. All rights reserved.
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