Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 42, Issue 1, Pages 99-102Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2006.07.013
Keywords
leishmanicide; Leishmania amazonensis; Baylis-Hillman adducts
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Sixteen not new aromatic compounds were prepared by one-pot reaction i.e. through Baylis-Hillman reaction and were the first time evaluated against promastigote Leishmania amazonensis and infected mammalian cells. Most of the compounds were selectively more active against amastigotes than the reference drug sodium stibogluconate (Pentostam, IC50 = 44.7 mu M). We found that 3-hydroxy-2-methylene-3-(4-broinophenyl)propanenitrile (13) was the most active (IC50 = 12.5 mu M) and safer compound (0.0 (0.9); % macrophage LDH release), being the lead compound. (c) 2006 Elsevier Masson SAS. All rights reserved.
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