Journal
MOLECULAR AND BIOCHEMICAL PARASITOLOGY
Volume 151, Issue 1, Pages 118-128Publisher
ELSEVIER
DOI: 10.1016/j.molbiopara.2006.10.014
Keywords
E. histolytica; HM-1 : IMSS; Rahman; microarray; strain comparison; proteomics
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Funding
- NIAID NIH HHS [U54AI057160, AI0717225, AI37977, AI30084] Funding Source: Medline
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U54AI057160, P01AI037977, R01AI030084] Funding Source: NIH RePORTER
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The availability of Rahman, and the virulent HM-1:IMSS strain of E. histolytica, provides a powerful tool for identifying virulence factors of E. histolytica. Here we report an attempt to identify potential virulence factors of E. histolytica by comparing the transcriptome of E. histolytica HM-1:IMSS and E. histolytica Rahman. With phenotypically defined strains, we compared the transcriptome of Rahman and HM-1:IMSS using a custom 70mer oligonucleotide based microarray that has essentially full representation of the E. histolytica HM-1:IMSS genome. We find extensive differences between the two strains, including distinct patterns of gene expression of cysteine proteinases, AIG family members, and lectin light chains. (c) 2006 Elsevier B.V. All rights reserved.
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