Journal
UROLOGIA INTERNATIONALIS
Volume 79, Issue 4, Pages 287-296Publisher
KARGER
DOI: 10.1159/000109711
Keywords
prostate cancer; neuroendocrine differentiation; chromogranin A; NeuroD1; LNCaP
Categories
Ask authors/readers for more resources
Objectives: To discuss the current knowledge on induction, production, sustenance and promotion of neuroendocrine differentiation in human prostate cancer. Methods: Review literature using PubMed search and scientific journal Results: Morphological evidence explains some functional relationship between neuroendocrine and surrounding cells. Transdifferentiation phenomenon and new biochemical pathways could be included in the development of androgen independence and prostate progression. Conclusion: Multiple evidence seems to that a synergistic functional network between epithelial PSA secretory cells and neuroendocrine intraprostatic system is the main trigger for the induction and sustenance of neuroendocrine differentiation. The development of new antineoplastic molecules should consider the multiple of the intercellular network. Copyright (c) 2007 S. Karger AG, Basel.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available