Journal
CANCER PREVENTION RESEARCH
Volume 4, Issue 4, Pages 473-475Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1940-6207.CAPR-11-0066
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- NCI NIH HHS [R01 CA096840] Funding Source: Medline
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Recent studies have shown associations between human population single-nucleotide polymorphisms (SNP) and white blood cell telomere shortness; independently, telomere shortness has been associated with higher risks of various cancers. However, no single previous study simultaneously linked a given SNP both with telomere length and reduced risk of cancer. In this issue of the journal (beginning on page 514), Gu and colleagues report four new SNPs associated, in three cohorts, with telomere length. One of these SNPs predicted risk for bladder cancer, an effect partially mediated by telomere length. Interventions that could forestall telomere shortening should be explored for their potential to reduce cancer risks. Cancer Prev Res; 4(4); 473-5. (C) 2011 AACR.
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