Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 33, Issue 12, Pages 1332-1339Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040701741810
Keywords
nanosuspensions; poorly soluble drugs; high-pressure homogenization; oridonin
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This study describes the preparation of an oridonin (ORI) nanosuspension by high-pressure homogenization (HPH). The aim was to obtain a stable nanosuspension with an increased drug saturation solubility and dissolution velocity. The homogenization procedure was optimized in regard to particle size and long-term stability. The characteristics of the oridonin nanosuspension, such as particle size, size distribution, shape, and zeta potential, were evaluated following the water removal. The solubility and dissolution experiments were performed to verify the obvious improvement of the dissolution behavior compared with commercial ORI. Finally, crystalline state evaluation before and following the formulation was performed through differential scanning calorimetry (DSC) and powder X-ray (PXRD).
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