Journal
GLIA
Volume 55, Issue 1, Pages 46-56Publisher
WILEY
DOI: 10.1002/glia.20435
Keywords
connexin; astrocytes; oligodendrocytes
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Funding
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [K02NS050345, R01NS042878, R01NS050705] Funding Source: NIH RePORTER
- NINDS NIH HHS [K02 NS050345-01, K02 NS050345, R01 NS050705, R01 NS42878, R01 NS050705-01A1, R01 NS050705-01] Funding Source: Medline
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Pannexins are a newly described family of proteins that may form gap junctions. We made antisera against mouse pannexin1 (Panx1). HeLa cells expressing Panx1 have cell surface labeling, but not gap junction plaques, and do not transfer small fluorescent dyes or neurobiotin in a scrape-loading assay. Neuro2a cells expressing Panx1 are not electrophysiologically coupled. Intracellular Panx1-immunoreactivity, but not gap junction plaques, is seen in cultured oligodendrocytes, astrocytes, and hippocampal neurons. Thus, at least in these mammalian cells lines, Panx1 does not form morphological or functional gap junctions, and it remains to be demonstrated that Panx1 forms gap junction-forming protein in the CNS. (c) 2006Wiley-Liss, Inc.
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