Journal
EXPERT OPINION ON BIOLOGICAL THERAPY
Volume 7, Issue 1, Pages 113-122Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1517/14712598.7.1.113
Keywords
BiovaxID(TM); clinical trials; idiotype; inununotherapy; lymphoma; rituxiinab; vaccine
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The clonal immunoglobulin molecule, idiotype (ID), expressed on the surface of B-cell malignancies can function as a tumor-specific antigen. BiovaxID(TM) is a patient-specific therapeutic cancer vaccine composed of the tumor idiotype conjugated to a carrier protein, keyhole limpet hemocyanin (KLH). In a Phase II clinical trial, administration of ID-KLH vaccine together with granulocyte-macrophage colony-stimulating factor to follicular lymphoma patients in complete remission induced tumor-specific cellular and humoral immunity and molecular remissions, and was associated with prolonged disease-free survival. A randomized, double-blind, Phase III clinical trial is ongoing to definitively determine the clinical benefit of BiovaxID plus granulocyte-macrophage colony-stimulating factor vaccination in patients with follicular lymphoma.
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