Journal
AUTOPHAGY
Volume 3, Issue 1, Pages 45-47Publisher
TAYLOR & FRANCIS INC
DOI: 10.4161/auto.3416
Keywords
cell death; sphingosine 1-phosphate; sphingosine kinase; ceramide; cancer; sphingolipids
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Sphingolipids are major constituents of biological membrane and some of them behave as second messengers involved in the cell fate decision. Ceramide and sphingosine 1-phosphate (S1P) constitute a rheostat system in which ceramide promotes cell death and S1P increases cell survival. We have shown that both sphingolipids are able to trigger autophagy with opposing outcomes on cell survival. Here we discuss and speculate on the diverging functions of the autophagic pathways induced by ceramide and SIP, respectively.
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