Journal
ONCOLOGY
Volume 72, Issue 5-6, Pages 371-380Publisher
KARGER
DOI: 10.1159/000113147
Keywords
colorectal cancer; Reg IV; serial analysis of gene expression; serum tumor marker
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Objective: Regenerating islet-derived family, member 4 (regenerating gene type IV, Reg IV) is overexpressed in colorectal cancer (CRC). The aim of this study was to investigate the diagnostic utility of Reg IV determination in sera from patients with CRC. Methods: We examined the expression and distribution of Reg IV in CRC by immunohistochemistry and determined Reg IV levels in sera from patients with CRC by enzyme-linked immunosorbent assay. Results: Immuno staining revealed that 23 of 80 (29%) CRC cases were positive for Reg IV. CRC cases with metastatic recurrence in the liver showed more frequently Reg IV staining than those without (p = 0.0102). Patients with CRC showing Reg IV staining had a significantly worse survival than those without Reg IV staining ( p = 0.0117). Preoperatively, serum Reg IV concentrations were not elevated in CRC patients at stage 0-III, being in contrast to the significantly increased preoperative levels in stage IV CRC patients with liver metastasis. Conclusion: These results suggest that Reg IV is a prognosticator for poor survival. Serum Reg IV concentration may predict CRC recurrence in the liver. Copyright (C) 2008 S. Karger AG, Basel.
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