Journal
CANCER PREVENTION RESEARCH
Volume 2, Issue 12, Pages 1003-1007Publisher
AMER ASSOC CANCER RESEARCH
DOI: 10.1158/1940-6207.CAPR-09-0232
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Funding
- NIEHS NIH HHS [P01 ES006052, P30 ES003819] Funding Source: Medline
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This perspective on Jubert et al. (beginning on page [1015] in this issue of the journal) discusses the use of microdosing with environmental carcinogens to accelerate the evaluation and optimization of chemopreventive interventions. The need for chemoprevention of environmental carcinogenesis is considered, as are the structure of microdosing, or phase 0, trials, technologies required to conduct microdose studies in this context, and ethical concerns. We also reflect on what microdosing studies have taught us to date.
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