Journal
MOLECULAR BIOSYSTEMS
Volume 3, Issue 1, Pages 18-23Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b611613m
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Funding
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R37AI020201, R01AI031882] Funding Source: NIH RePORTER
- NIAID NIH HHS [R01-AI31882, R01-AI57362, R37AI-20201] Funding Source: Medline
- PHS HHS [R01-A1-71342] Funding Source: Medline
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Influenza A and viruses encode minimalistic proton-selective ion channels known as A/M2 and BM2, respectively. The A/M2 channel is the target of the antiviral drug, amantadine. The structural and mechanistic aspects of proton conductance of the viral ion channels are described and the review makes a case for the development of more effective antivirals.
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