Journal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
Volume 33, Issue 10, Pages 1043-1057Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03639040701525627
Keywords
hot-melt extrusion; solid dispersion; bioavailability; melt-extruded tablets; drug delivery systems; melt extruded films
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Funding
- NCRR NIH HHS [P20RR021929] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [P20RR021929] Funding Source: NIH RePORTER
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The advent of high through-put screening in the drug discovery process has resulted in compounds with high lipophilicity and poor solubility. Increasing the solubility of such compounds poses a major challenge to formulation scientists. Various approaches have been adopted to address this including preparation of solid dispersions and solid solutions. Hot-melt extrusion is an efficient technology for producing solid molecular dispersions with considerable advantages over solvent-based processes such as spray drying and co-precipitation. Hot-melt extrusion has been demonstrated to provide sustained, modified, and targeted drug delivery. Improvements in bioavailability utilizing the hot-melt extrusion technique demonstrate the value of the technology as a potential drug delivery processing tool. The interest in hot-melt extrusion technology for pharmaceutical applications is evident from the increasing number of patents and publications in the scientific literature. Part II of this article reviews the myriad of hot-melt extrusion applications for pharmaceutical dosage forms including granules, pellets, tablets, implants, transmucosal, and transdermal systems.
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