Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 2, Issue 1, Pages 20-38Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.200600310
Keywords
asymmetric synthesis; lactacystin; lactams; natural products; salinosporamide A
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Lactacystin and salinosporamide A are fascinating molecules with regard to both their chemical structures and biological activities. These naturally occurring compounds are potent and selective proteasome inhibitors. The molecular structures are characterized by their densely functionalized gamma-lactam cores. The structure and biological properties of these two compounds are attracting the attention of many chemists as challenging synthetic targets. We discuss their synthetic strategies in this review.
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